Diving into the world of research, there are some significant insights into how smoking affects people with ankylosing spondylitis (AS). AS, a member of the axial spondyloarthritis family, majorly targets the spine and where the spine meets the pelvis.

Recent findings from a comprehensive British study reveal that folks with AS who smoke often face swifter spinal damage, a key characteristic of this arthritis type. What's more? Smokers with AS often experience a dip in their mood and overall quality of life.

Dr. Sizheng (Steven) Zhao, who spearheaded this study, emphasizes how smokers with this condition consistently report deteriorating health compared to non-smokers. Interestingly, smokers also show heightened anxiety, depression, disrupted sleep, fatigue, and even a connection with psoriasis, another autoimmune condition.

Delving deeper, while both men and women smokers with AS experience exacerbated disease symptoms, the effects are notably harsher for men. And guess what? Men who kick the habit experience notable improvements! Although the reasons behind these gender differences are still under the microscope, it's worth noting that men often smoke more heavily than women.

Other intriguing findings suggest that male smokers with AS might face a faster disease progression. Some even develop bony growths leading to spinal fusion, which can be incredibly painful and limit movement.

The big question remains: Why does smoking intensify AS? Many researchers believe that the inflammation from smoke inhalation may accelerate the damage. Yet, understanding the full picture is tricky as smokers often juggle other health and lifestyle factors that could influence AS.

But here's a silver lining: Quitting can make a world of difference! Former smokers with AS generally have lower disease activity and enjoy a better quality of life than those who still light up. The benefits? Think of them as akin to the positive impacts of dedicated physical therapy and specific medications.

To wrap it up, as Dr. Zhao rightly points out, apart from the obvious health hazards like heart diseases and cancers, smoking significantly boosts the risk of cardiovascular diseases, especially for those with rheumatic conditions like AS. So, championing a smoke-free life, along with embracing a balanced diet and regular exercise, is the way to go for overall well-being.